gp130/IL6ST Gene IL6ST gene / cDNA is a protein-coding gene which located on 5q11.2. The IL6ST gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.218 organisms have orthologs with human gene IL6ST.
Absence of GP130 cytokine receptor signaling causes extended Novel genetic and epigenetic factors of importance for inter-individual differences in drug polymorphism in the genes of leukemia inhibitory factor receptor and gp130 gp130 gene and two SNPs in the LIFR gene were analyzed using real-time PCR. Uppsats: Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130. In both cases, association with the signal transducing gp130 receptor is compulsory. However, differences in the downstream signaling mechanisms of IL-6 Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp1302010Självständigt LIBRIS titelinformation: Gene Knockout Factsbook [Elektronisk resurs] / [edited by] Tak W. mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders. macrophages in pathogenesis of inflammatory bowel disease · Retinoic acid in acute ischemia and heart failure: from genes to left ventricular performance Reciprocal regulation of gastrointestinal homeostasis by SHP2 and. STAT-mediated trefoil gene activation in gp130 mutant mice.
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Fig. S6. The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene.. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. 2000-02-08 In humans, there are two chromosomal loci for gp130; one is the genuine gp130 gene, located on chromosome 5q11, and the other is a pseudogene localized to chromosome 17. The murine and rat gp130 genes are located on chromosomes 13 and 2q14–q16, respectively (Table 1). The human gp130 gene has 17 exons gp130/IL6ST Gene.
Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family.
Cell Genet. (1995) Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop. Gp130 is most closely related to GCSFR (CSF3R; 138971). Both receptors contain 6 fibronectin (135600) type III modules in the extracellular region.
genes co-occuring with the biological term gp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. CNTF-CNTFR- gp130 -LIFR complex Gene Set
Previous studies have identified Gene expression analyses showed that Pam2 treatment resulted in increased of inflammation- induced new bone formation may be due to enhanced gp130 Comparative evaluation of gp130 signalling cytokines in human endothelial cells: evidence for both specific and overlapping molecular responses Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis.
GO annotations related to this gene include interleukin-6 receptor binding and protein homodimerization activity . In the present study, we investigated the possibility that activation of gp130 initiates activation of the cytoprotective genes in cardiac myocytes. Incubation of cardiac myocytes with LIF induced the expression of bcl-x, and the isoform that was induced by LIF was identified as bcl-xL. gp130 is associated with adverse postoperative clinical outcomes of patients with late-stage non-metastatic gastric cancer. GP130 signaling is required for tumor cell survival in diverse forms of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations. 2019-08-08 · Third, L-gp130 BM and manifest tumors are transplantable, allowing additional gene editing of FL and BM cells in vitro with subsequent syngeneic transplantation. Fourth, beyond the context of tumor pathogenesis, it allows targeting of gp130/JAK/STAT3 activation to specific cellular components or tissues that are involved in inflammation and immunity, e.g., in arthritis ( 8 ).
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Full gene Candidate cardiovascular disease genes Abstract. The gene IL6ST encodes GP130, the common signal transducer of the IL-6 cytokine family consisting of 10 cytokines.
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is
Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte A mutation in the CART gene in humans is associated with reduced
Abstract : Fusion genes represent a growing class of translocation-derived potent receptor (IL6R) which associates with the signal transducing receptor gp130. >tr|A2VD21|A2VD21_DANRE Brain POU domain gene 1.2 OS=Danio rerio >tr|A8WH79|A8WH79_DANRE Gp130 protein OS=Danio rerio GN=il6st PE=2
genetic polymorphism. MeSH-ID. D020641.
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Single‐sample Gene Set Enrichment Analysis (ssGSEA) 33 was used to investigate a three‐gene signature (CXCL13, CCL19, CCL21) linked with TLS development in gp130 F/F mice. This data was also validated in an independent cohort of intestinal‐type GC patients from the Asian Cancer Research Group (ACRG; GEO accession number GSE62254). 34
Protein gene expression and surface expression in NK92 cells of ciliary neurotrophic factor alpha (CNTFR-alpha) and glycoprotein (gp)130 in natural killer (NK) cells, in the context of malaria, were investigated. gp130 (glycoprotein 130), a coreceptor of oncostatin M, is essential for cardiomyocyte proliferation and heart regeneration. The proproliferative effect of gp130 in cardiomyocytes is mediated by Src-Yap (Y357 phosphorylation) independently of the Hippo pathway, completing the mechanism of heart regeneration.